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KMID : 0861020190340030031
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Korea Journal of Herbology
2019 Volume.34 No. 3 p.31 ~ p.36
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Single Oral Dose Toxicity Test of Standardized Cornus officinalis andPsoralea corylifolia L. Extracts in Sprague-Dawley Rat
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Jin Bo-Ram
Kang Hyun-Ae
Cominguez Divina C.
Kim Myoung-Seok
Lee Kwang-Ho
Yoon Il-Joo
An Hyo-Jin
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Abstract
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Objectives : In this animal study, we performed the single oral dose toxicity test of Standardized Cornus officinalis Sieb. et Zucc. and Psoralea corylifolia L. 30% ethanol extract (SCP) in Sprague-Dawley (SD) rats owing to aims for verifying approximate lethal dose (ALD).
Methods : According to OECD guidelines for the testing of chemicals section 4 health effects test No. 420 acute oral toxicity study ? fixed dose procedure (17 December 2001), single oral dose toxicity test was performed. Animals were divided into two groups: Group 1, vehicle-treated rats (Control); Group 2, SCP 5000 ㎎/㎏ treated rats. SCP is composed of two medicinal herbs: Cornus officinalis Sieb. et Zucc. (650 g) and Psoralea corylifolia L. (350 g) in 30% ethanol. SCP was once orally administered to female and male SD rats at dose levels of 5000 ㎎/㎏. Animals were monitored on the mortality, clinical signs, body weight changes and necropsy findings for 14 days.
Results : After single oral treatment of SCP, we could not find any mortality up to 5000 ㎎/㎏. Compared with the control group, there were also no significant differences in clinical sign, weight change, weight gain and gross abnormalities in SCP 5000 ㎎/㎏-treated group.
Conclusions : Taken together, these results suggest that the ALD of SCP in both female and male SD rats were considered as over 5000 ㎎/㎏. Results from this study provide scientific evidence for the safety of SCP.
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KEYWORD
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Cornus officinalis, Psoralea corylifolia L., single oral dose toxicity, SD rats, Single Oral Dose Toxicity Test
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